Much is known about the antecedents and outcomes of procrastination when comparing students to one another. However, little is known about the antecedents and outcomes of procrastination when comparing the courses taken by the students during a semester. In this study, we proposed that examining procrastination at both levels of analysis should improve our understanding of the academic experience of students. At both levels, we examined the mediating role of procrastination in the associations between two dimensions of motivation and indicators (...) of academic achievement and well-being. A sample of 359 university students completed questionnaires measuring their motivation, procrastination, and affect in each of their courses. The official final course grades were obtained at the end of the semester. Multilevel mediation analyses with structural equation modeling were conducted to test our hypotheses. At the between-person level, the indirect effects revealed that higher controlled motivation was significantly associated with worse outcomes via higher levels of procrastination. At the within-person level, the indirect effects revealed that lower autonomous motivation was significantly associated with worse outcomes via higher levels of procrastination. Overall, this study shows that different pathways at each level of analysis may explain how procrastination can be detrimental for the success and well-being of university students. (shrink)

J. L. Schellenberg’s Divine Hiddenness and Human Reason offers an argument for the non-existence of God. He argues that God’s existence isn’t evident and, thus, there exist cases of “reasonable nonbelief”. But, such nonbelief is inconsistent—Schellenberg argues—with the existence of a loving God desiring a personal relationship with others. In short, if (a perfectly loving) God exists, then reasonable nonbelief must be impossible. But, since there is such belief, we have good reason to think God doesn’t exist. In (...) this chapter, I argue that there is a way to resist Schellenberg’s conclusion because there is a reason that God might not make God’s existence evident. I begin by showing that the problem of hiddenness is a version of the problem of evil. Here, the obscurity of God’s existence is a kind of intellectual bad state akin to traditional moral or natural evils. This opens the door to a modified response to hiddenness based on approaches to the standard problem of evil. I take Hick’s soul making theodicy as the guiding theory altered to fit hiddenness. Hick appeals to the moral development in overcoming evil, whereas I focus on the development of faith in God as the kind of soul making feature hiddenness can spur. If God’s existence isn’t evident, the uncertainty here can promote robust trust in God and, through that faith, can provide a good reason that God might remain hidden. (shrink)

It is erudite, broad-ranging, respectful of the actors involved, sympathetic, and nuanced. This is the first book of its kind."--Ronen Palan, University of Birmingham "I thoroughly enjoyed reading this book.

:High-fidelity simulation is a relatively new teaching modality, which is gaining widespread acceptance in medical education. To date, dozens of studies have proven the usefulness of HFS in improving student, resident, and attending physician performance, with similar results in the allied health fields. Although many studies have analyzed the utility of simulation, few have investigated why it works. A recent study illustrated that permissive failure, leading to simulated mortality, is one HFS method that can improve long-term performance. Critics maintain, however, (...) that the use of simulated death is troubling and excessive. Given the controversy regarding simulated death, we consider the data about the educational value and the emotional harms associated with them, expecting that evidence could be useful in resolving the question. The goal of this narrative review is to explore the argument against simulated mortality and provide educators with an imperative as to why it can be safely utilized. (shrink)

In this essay, I offer an interpretation of the ethical thought of Elizabeth Anscombe, Philippa Foot, Mary Midgley, and Iris Murdoch. The combined effect of their work was to revive a naturalistic account of ethical objectivity that had dominated the premodern world. I proceed narratively, explaining how each of the four came to make the contribution she did towards this implicit common project: in particular how these women came to see philosophical possibilities that their male contemporaries mostly did not.

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 40.1 (2002) 126-127 [Access article in PDF] Book Review Natural Law Theories in the Early Enlightenment T. J. Hochstrasser. Natural Law Theories in the Early Enlightenment. New York: Cambridge University Press, 2000. Pp. xiii + 246. Cloth, $54.95. In a worthy addition to Cambridge's Ideas in Context series, T. J. Hochstrasser undertakes an excavation. His aim is to provide a description, and to (...) demonstrate the importance within the German Frühaufklärung, of a largely forgotten philosophical approach: eclecticism. Hochstrasser argues that the triumph of Wolffian rationalism in the Protestant universities in the middle of the eighteenth century occluded the importance of eclecticism for Kant, who in turn occluded it for everyone afterward. But the price of forgetting eclecticism is high. Not only are we left with no account--or a skewed account--of the development of German thought from the first stirrings of the Enlightenment to the emergence of the Critical philosophy, but our understanding of the development of the historiography of philosophy is badly compromised. For among their many accomplishments--in natural jurisprudence, in university reform--the eclectics were the first critical historians of philosophy, their distinctive genres being historically aware treatises on natural law and Whig histories of natural jurisprudence. Hochstrasser's study traces the development of eclecticism, from the work of its founders, Samuel Pufendorf and Christian Thomasius, through a devolution in the hands of Thomasius's later disciples, to the eventual oblivion in the middle of the eighteenth century. This review will focus on the beginning of this narrative, as Pufendorf is the leading figure in the book.Eclecticism began with Pufendorf's attempt, in his mature work on natural law, to reconcile his conflicting inheritances from Grotius and Hobbes without simply endorsing the work of either. He was impressed both by Grotius's explanation of the law of nations in terms of human sociability--but also by Hobbes's criticisms of Grotius, rooted in the latter's analysis of the state of nature. At the same time, he wished to reject Grotius's method of induction from sociological observation and Hobbes's minimally constrained voluntarism. Contributing further to his perplexity was his increasing disaffection from the geometric approach he had adopted in his Elementa Jurisprudentiae Universalis.The way out of this impasse, Hochstrasser contends, was revealed to Pufendorf in correspondence with Hermann Conring, the leading constitutional lawyer of his time, and Johann Böcler, Grotius's most erudite commentator. Böcler chastised Pufendorf for his neglect of history, and both of Pufendorf's correspondents pointed out his need for some non-Hobbesian criterion by which he could validate his first principles, whatever they turned out to be. Stung particularly by Böcler's remarks, Pufendorf returned to the Stoics and there discovered a via media between Hobbes's pessimism and Grotius's optimism: a synthesis anticipating Kant's doctrine of "unsocial sociability." For the purposes of Hochstrasser's study, the key aspects of Pufendorf's solution are these: first, it avoids mere voluntarism; second, it does this by means of a moral epistemology that sharply distinguishes natural law [End Page 126] from moral theology; finally, the validating criterion for Pufendorf's first principles is located in critical appropriation of the history of moral philosophy. These were to be hallmarks of Pufendorf's school.On the first and second points, Hochstrasser seems to me substantively correct, though I think he misunderstands the nature of Pufendorf's escape from mere voluntarism and thereby underplays the religious dimensions of Pufendorf's theory. Among recent Anglo-American commentators on Pufendorf, only Robert Adams has in my view properly construed Pufendorf's thought: that it involves a command theory of obligation proper, but posits the natural advantageousness of some hierarchies as a buttress against mere voluntarism. Hochstrasser is thus right to insist, against Leibniz, that Pufendorf's account of obligation is coherent. But he is wrong to suggest that "there was nothing in Pufendorf's theory... to oblige him to introduce fear of punishment by a superior... " (105). He is... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Contexts and Dialogue: Yogācāra Buddhism and Modern Psychology on the Subliminal Mind, and: SciousnessBenjamin J. ChickaContexts and Dialogue: Yogācāra Buddhism and Modern Psychology on the Subliminal Mind. By Tao Jiang. Honolulu: University of Hawai‘i Press, 2006. xi + 198 pp.Sciousness. Edited by Jonathan Bricklin. Guilford, CT: Eirini Press, 2006. 229 pp.It has become popular to view Buddhist concepts as nothing more than self-help techniques. The tradition, stripped of (...) religious content, is now used to foster human growth. Given such interests, psychological comparisons have become prevalent and Buddha has been understood as the first to explore the ego. This is a review of two books—Jiang’s Contexts and Dialogue and Bricklin’s Sciousness—approaching such developments from different directions. In Contexts and Dialogue, Tao Jiang worries that jumping into comparison too hastily risks losing original meanings when words are made relative to whatever structure in which they are placed. The original contexts of Yogācāra Buddhism and modern psychology both need to be understood in order to reveal existing presuppositions about how the two can be brought together. Jonathan Bricklin’s Sciousness has more hope for comparative work because he believes he has found an untapped resource for comparison in the theory of sciousness developed by William James (1842–1910). Pragmatic philosophy has yet to be compared with Buddhist traditions in depth, even though both favor practical solutions to problems over merely theoretical pondering.Jiang is a specialist in comparative philosophy. His method is to deconstruct current comparisons between different systems by recovering the original meanings of their different terminologies in their original context and in relation to the particular problems each system was addressing. Comparison can then be reconstructed out of these original contexts so that genuine similarities and differences can emerge. Regarding Yogācāra thought, the systematic theory of mind /consciousness, ālayavijñāna (“storehouse consciousness”) is at its center. This “storehouse of consciousness” is a subliminal reservoir for memories and habits that has made a correlation with the psychological unconscious tempting (pp. 9–10). However, rather than ask whether ālayavijñāna can serve the needs of modern psychology, Jiang first explores what problem it was originally meant to address. He achieves this goal by examining the seventh-century Chinese Buddhist work Cheng Weishi Lun (Discourse on the Perfection of Consciousness-only) of the Buddhist monk pilgrim Xuanzang (Hsüan-tsang, ca. 600–664). Only when this journey is complete does Jiang compare [End Page 201] ālayavijñāna to the psychological theories of Sigmund Freud (1856 –1939) and Carl Jung (1875–1961). The result Jiang argues for is that notions of transcendence and immanence are emphasized differently in the three theories of consciousness offered by Xuanzang, Freud, and Jung.Yogācārins were dealing with deep meditative states in which consciousness is supposed to cease and with the problem of how meditators could arise from such meditative states without violating the doctrine of anātman (“no-self ”). What supports the meditator in these states if no enduring substantive self exists? How can there be identity and change without substantial reification? On the other hand, how can impermanent existence account for the seeming continuity of the world we experience?The answer given by Xuanzang is that an empirical self can be embraced while a metaphysical one is rejected. However, without such a metaphysical self, the question of “whose” arises (p. 27). Whose consciousness of continuous experience is being dealt with if not that of a metaphysical self? The radical solution offered is that ālayavijñāna contains subliminal seeds that produce continuity between successive dharma moments. This solution must be possible without violating the simultaneity of cause and effect. Thus, Xuanzang spoke of dharmas as actual and bījas, seeds of the potential for production, as only potential (p. 60). Perishing dharmas are maintained by the seeds to be manifested in the future and substantive entities are not introduced because seeds are only potential (p. 42). The result is that after deep meditative states when mental activities halt, the mind can emerge from the seeds of mental activity without needing antecedent actual mental activity.Xuanzang’s approach... (shrink)

Discusses three concepts crucial to an understanding of the nature of religion: anxiety, guilt, and freedom. The various essays examine these from the viewpoint of several different religious traditions, movements and thinkers. Contents: Editor's Preface. Donald Gard: A Personal Perspective. Part I. Guiltless Morality; The Family of Changing Woman: Nature and Women in Navaho Thought; The Sacraments as "Fear-provoking" and "Awe-inspiring" Rites in the Greek Fathers; The Doctrine of Karma; Two Concepts of Predestination in Current Islamic Thought. Part II. The (...) Spirit of Medieval Penitents; The Evolution of Freedom as Catholicity in Catholic Ethics; Agape and the Liberation Movements. Part III. Calvin's Idea of Freedom in the Ethics of Schleiermacher and Barth; Creativity and Freedom in the Thought of Martin Buber; The Liberating Visions of C. G. Jung; 'The World's Most Perverse Habit'; Appendix: Study Questions. (shrink)

Discusses three concepts crucial to an understanding of the nature of religion: anxiety, guilt, and freedom. The various essays examine these from the viewpoint of several different religious traditions, movements and thinkers. Contents: Editor's Preface. Donald Gard: A Personal Perspective. Part I. Guiltless Morality; The Family of Changing Woman: Nature and Women in Navaho Thought; The Sacraments as 'Fear-provoking' and 'Awe-inspiring' Rites in the Greek Fathers; The Doctrine of Karma; Two Concepts of Predestination in Current Islamic Thought. Part II. The (...) Spirit of Medieval Penitents; The Evolution of Freedom as Catholicity in Catholic Ethics; Agape and the Liberation Movements. Part III. Calvin's Idea of Freedom in the Ethics of Schleiermacher and Barth; Creativity and Freedom in the Thought of Martin Buber; The Liberating Visions of C. G. Jung; 'The World's Most Perverse Habit'; Appendix: Study Questions. (shrink)

This essay is a reading of Aristotle’s account in Meteorology I.14 of changes in local environmental conditions and its significance for Aristotle’s understanding of nature and change more generally. That account shows how local environments are complex bodies, and so change through habituation: the sedimentation of patterns of activity through repeated activity/change. In turn, this shows how the regularity of what is by nature is a matter of the relative stability of habits in the face of unceasing generation and destruction. (...) Strikingly, Aristotle then turns to the consequences of that account for human beings’ ability to comprehend changes in the environmental conditions of their activities. (shrink)

Mark McCreary has argued that I cannot consistently advance both the hiddenness argument and certain arguments for religious scepticism found in my book The Wisdom to Doubt . This reaction was expected, and in WD I explained its shortsightedness in that context. First, I noted how in Part III of WD , where theism is addressed, my principal aim is not to prove atheism but to show theists that they are not immune from the scepticism defended in Parts I and (...) II. To the success of this aim, McCreary's arguments are not so much as relevant, for a thoroughgoing scepticism embracing even the hiddenness argument is quite compatible with its success. But I also explained how someone convinced that the hiddenness argument does prove atheism escapes the grip of religious scepticism because of that argument's reliance on apparent conceptual truths. McCreary's critique obscures this point but does not defuse it. (shrink)

In this second of two essays responding to critical discussion of my " Divine Hiddenness and Human Reason," I show how an ' accommodationist ' strategy can be used to defuse objections that were not exposed as irrelevant by the first essay. This strategy involves showing that the dominant concern of reasons for divine withdrawal can be met or accommodated within the framework of divine - human relationship envisaged by the hiddenness argument. I conclude that critical discussion leaves the argument (...) very much alive and kicking, and indeed strengthened as it moves into its second decade of life. (shrink)

In this brief reply I argue that criticisms of the hiddenness argument recently published in this journal by Imran Aijaz and Markus Weidler are without force. As will be shown, their critique of my conceptual version of the argument misses the mark by missing crucial distinctions. Their critique of my analogical version of the argument misunderstands that argument and also misapplies the work of W. H. Vanstone. And their critique of my view that belief is necessary for a certain kind (...) of relationship with God overlooks both some central features of that kind of relationship and some good reasons for not accepting acceptance or anything similarly nonbelieving as a substitute for belief in this context. (shrink)

Some Christian philosophers wonder whether a God really would oppose reasonable nonbelief. Others think the answer to the problem of reasonable nonbelief is that there isn’t any. Between them, Douglas V. Henry and Robert T. Lehe cover all of this ground in their recent responses to my work on Divine hiddenness. Here I give my answers to their arguments.

Some Christian philosophers wonder whether a God really would oppose reasonable nonbelief. Others think the answer to the problem of reasonable nonbelief is that there isn’t any. Between them, Douglas V. Henry and Robert T. Lehe cover all of this ground in their recent responses to my work on Divine hiddenness. Here I give my answers to their arguments.

Only 6 years have passed since I last published a critical survey article on the divine hiddenness discussion. But more than 60 papers and books dealing with hiddenness themes have been published in that time. Not all can be addressed here. Moreover, to enable a reasonable treatment of those that will make an appearance, I shall break the present survey into two parts. I begin in this piece with recent work—including my own—on the argument descended from Schellenberg (), which (...) started the discussion. Part 2, yet to come, will consider ways in which this area of inquiry has recently been enlarged beyond its original parameters. (shrink)

Offered here is Part 2 of a two-part critical survey of recent work in philosophy on divine hiddenness. Part 1 surveyed recent development of the discussion initiated by my 1993 book on the subject. Here, I examine some related work that expands the scope of the hiddenness discussion. Some of the enlargements take further the discussion of Stephen Maitzen's work on the demographics of theism. Others introduce new hiddenness problems and ways of dealing with them. A third category of new (...) work urges theological constraints, of one sort or another, on hiddenness reasoning, thus raising new methodological issues. (shrink)

Mark McCreary has argued that I cannot consistently advance both the hiddenness argument and certain arguments for religious scepticism found in my book The Wisdom to Doubt (WD). This reaction was expected, and in WD I explained its shortsightedness in that context. First, I noted how in Part III of WD, where theism is addressed, my principal aim is not to prove atheism but to show theists that they are not immune from the scepticism defended in Parts I and II. (...) To the success of this aim, McCreary's arguments are not so much as relevant, for a thoroughgoing scepticism embracing even the hiddenness argument is quite compatible with its success. But I also explained how someone convinced that the hiddenness argument does prove atheism escapes the grip of religious scepticism because of that argument's reliance on apparent conceptual truths. McCreary's critique obscures this point but does not defuse it. (shrink)

In this article I state concisely the central features of a new logical problem of evil developed elsewhere and take account of a response to this problem recently published in this journal by Jerome Gellman. I also reflect briefly on how theology can play a role in such philosophical discussions.

In this paper I argue that given the present state of relevant inquiry, the facts of religious diversity justify religious skepticism. Because of the diversity of religious claims, the denial of any detailed religious proposition is equivalent to a large disjunction of alternative claims. The same is true of the denial of metaphysical naturalism. And having typically acquired no detailed understanding of the whole panoply of religious views, religious believers and metaphysical naturalists are rarely in a position to judge, of (...) any such disjunction, how likely it is to be true. Now the investigative deficit here might conceivably be oversome, but the paper concludes by showing that even where it is overcome, we remain in conditions supporting religious skepticism because of the evolutionary immaturity of our species, which prevents us from being in a position to judge whether religious diversity as humans in the future – or some future species – will know it includes ideas about the Divine trumping any contrary ideas of today. (shrink)

Wykstra’s paper defends two objections to my reasoning in The Wisdom to Doubt. One says that we in fact do take evidence to be representative of all the relevant evidence that exists when forming the judgment that it makes some proposition probable, the other that our judgments as to the representativeness of evidence are often justified, and can be justified even in matters of religion. Both objections are instructive but ultimately unsuccessful, as I show here.

In his response to my trilogy, Jack MacIntosh suggests a variety of ways in which its conclusions may be challenged, drawing on considerations scientific, moral, and prudential. I argue that the challenges can be met, and, in the process, show how the trilogy’s reasoning can be extended and strengthened on a number of fronts.

In this paper I discuss a neglected form of argument against religious belief -- generically, 'the probabilistic argument from pluralism'. If the denial of a belief is equivalent to the disjunction of its alternatives, and if we may gain some idea as to the probabilities of such disjunctions by adding the separate probabilities of their mutually exclusive disjuncts, and if, moreover, the denials of many religious beliefs are disjunctions known to have two or more mutually exclusive members each possessing a (...) significant degree or probability, then at any rate in many such cases, the denial of a religious belief can be shown to be more probable than it is -- which is to say that the belief can be shown to be improbable. I consider a large number of responses to arguments of this form, concluding that none suffices to overthrow it altogether. Indeed, the argument remains as a significant threat to any religious belief confronted by a plurality of alternatives. (shrink)

Religious epistemology is widely regarded as being in a flourishing condition. It is true that some very sharp analytical work on religion has been produced by philosophers in the past few decades. But this work, for various cultural and historical reasons, has been kept within excessively narrow bounds, and the result is that the appearance of flourishing is to a considerable extent illusory. Here I discuss three important ways in which improvements to this situation might be made.

Corporate social responsibility (CSR) activities have become increasingly prevalent in retail settings. In franchised organizations, franchisors typically design and coordinate these activities, leaving operational execution to franchisees. Meanwhile, franchisors may introduce new corporate-led CSR activities over time. Even though changes to CSR activities may refocus outlets’ attention on a CSR initiative, they may also disrupt an outlet’s ongoing CSR routines. Using a longitudinal, secondary dataset consisting of an eight-year panel for a national, franchised restaurant chain, we examine CSR performance dynamics (...) in the presence of two distinct types of CSR activities: an ongoing CSR routine and a distinct, temporary CSR campaign. We find that, when resuming the CSR routine after a temporary CSR campaign, outlets’ performance in CSR routines drops significantly (i.e., immediate decay), then improves gradually (i.e., protracted recovery). We also consider the moderating role of an outlet’s experience, finding that experience stabilizes these decay and recovery cycles. Our findings represent a first step in developing a longitudinal understanding of how a firm’s short-term CSR campaigns may impact ongoing CSR routines, thus contributing to the knowledge of CSR activity development and routinization. (shrink)

In this article I state concisely the central features of a new logical problem of evil developed elsewhere and take account of a response to this problem recently published in this journal by Jerome Gellman. I also reflect briefly on how theology can play a role in such philosophical discussions.

In The Ethics of Food, Gregory E. Pence brings together a collection of voices who share the view that the ethics of genetically modified food is among the most pressing societal questions of our time. This comprehensive collection addresses a broad range of subjects, including the meaning of food, moral analyses of vegetarianism and starvation, the safety and environmental risks of genetically modified food, issues of global food politics and the food industry, and the relationships among food, evolution, and human (...) history. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

I seek to promote a fuller understanding of religious skepticism by defending five theses. These concern, respectively: its breadth, discussed in relation to theism on the one hand and naturalism on the other; why it should be distinguished from a general metaphysical skepticism; how it is supported by the consequences of recent cultural evolution, which at the same time enable new and stronger arguments for atheism; the relations it bears to non-doxastic religious faith; and, finally, its curious capacity in certain (...) not uncommon circumstances to take the form of a soft irreligion that is widely approvable—even from a religious perspective. (shrink)

Here I show how thinking of inquiry as immature can illuminate problems about metaphysical and scientific realism. I begin with the question whether human beings at the very beginning of systematic inquiry who held themselves to be thus situated, temporally speaking, and came to recognize their inability to prove or probabilify the truth of metaphysical realism would have been justified in believing or accepting metaphysical realism even so. Drawing on broadly Wittgensteinian ideas I defend an affirmative answer. Then I extrapolate (...) from this result, arguing by analogy that acceptance of both metaphysical realism and scientific realism is justified for us today. (shrink)

In this paper I argue that moral virtue is sometimes causally necessary both for theistic belief and for nonbelief. I then argue for some further connectionsbetween these results and the Calvinist view, recently revived in the philosophy of religion, according to which theistic belief is typically warranted and all those who dissent from such belief persist in their nonbelief because of sin. Specifically, I maintain that the virtue of belief militates against its being warranted, and that the virtue of nonbelief (...) renders the Calvinist generalization concerning nonbelief and sin implausible. (shrink)

In this paper I distinguish two levels of intellectual importance, derived and underived, showing how the former can be species-based. Then I do four things: first, identify a neglected way, stemming from perceived human intellectual maturity, in which many of us are vulnerable to a sense of species-based importance; second, show—in part by appealing to facts about deep time—that we have no right to this sense and so evince a failure of intellectual humility if we acquiesce in it; third, defend (...) the view that the claims of intellectual humility on those who would be overall rational are not in this regard overridden; and then, finally, gesture at some of the consequences of this result for inquiry. (shrink)

In this paper I explore and defend the idea that those who struggle intellectually in theistic religious practice can be given a good reason to persist in it by treating their continuing practice as a way of paying tribute to people and projects and personal relationships and indeed to the whole moral dimension of human life, expressing how important and profoundly significant these things are to them. This ‘tribute of faith’ is a gesture that one makes with one’s life—a moral (...) gesture. The key thought is that the sayings and other doings of a religious life allow one to treat the world as one in which the things, such as projects and people, that are, for one, most deeply imbued with moral value will achieve fulfilment—a fulfillment that without the truth of religious claims they would often be denied. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Identifying the necessary and sufficient conditions for individuating and classifying diseases is a matter of great importance in the fields of law, ethics, epidemiology, and of course, medicine. In this paper, I first propose a means of achieving this goal, ensuring that no two distinct disease-types could correctly be ascribed to the same disease-token. I then posit a metaphysical ontology of diseases—that is, I give an account of what a disease is. This is essential to providing the most effective means (...) of interfering with disease processes. Following existing work in the philosophy of medicine and epidemiology (primarily Christopher Boorse; Caroline Whitbeck; Alexander Broadbent), philosophy of biology (Joseph LaPorte; D.L. Hull), conditional analyses of causation (J.L. Mackie; David Lewis), and recent literature on dispositional essentialism (Stephen Mumford and Rani Anjum; Alexander Bird), I endorse a dispositional conception of disease. Following discussion of various conceptions of disease-identity, their relations to the clinical and pathological effects of the diseases in question, and how diseases are treated, I conclude (i) that diseases should be individuated by their causes, and (ii) that diseases are causal processes best seen as simultaneously acting sequences of mutually manifesting dispositions. (shrink)

"There is no attempt here to lay down as inviolable or to legislate certain ways of looking at things or ways of proceeding for philosophers of religion, only proposals for how to deal with a range of basic issues-proposals that I hope will ignite much fruitful discussion and which, in any case, I shall take as a basis for my own ongoing work in the field."-from the Preface Providing an original and systematic treatment of foundational issues in philosophy of religion, (...) J. L. Schellenberg's new book addresses the structure of religious and irreligious belief, the varieties of religious skepticism, and the nature of religion itself. From the author's searching analysis of faith emerges a novel understanding of propositional faith as requiring the absence of belief. Schellenberg asks what the aims of the field should be, setting out a series of principles for carrying out some of the most important of these aims. His account of justification considers not only belief but also other responses to religious claims and distinguishes the justification of responses, propositions, and persons. Throughout Prolegomena to a Philosophy of Religion, Schellenberg is laying the groundwork for an elaboration of his own vision while at the same time suggesting how philosophers might rethink assumptions guiding most of today's work in analytic philosophy of religion. (shrink)

While stakeholder theory has traditionally considered organization’s interactions with stakeholders in terms of independent, dyadic relationships, recent scholarship has pointed to the fact that organizations exist within a complex network of intertwining relationships [e.g., Rowley, T. J.: 1997, The Academy of Management Review 22(4), 887–910]. However, further theoretical and empirical development of the interactions between stakeholders has been lacking. In this paper, we develop a framework for understanding and measuring the effects upon the organization of competing, complementary and cooperative stakeholder (...) interactions, which we refer to as stakeholder multiplicity. We draw upon three forms of fit (i.e. fit as matching, fit as moderation, and fit as gestalts; Venkatraman, N.: 1989) to develop a framework for understanding stakeholder multiplicity based upon the direction, strength, and synergies of the interacting claims. Additionally, we draw upon the theory of stakeholder identification and salience of Mitchell et al. (1997), which we argue provides a more relevant and significantly more illustrative explanation of the nature and effects of stakeholder interactions upon the organization than the network approach of Rowley (1997). Furthermore, we ground our framework through reference to three stakeholder groups (i.e. governments, customers, and employees) and the stakeholder issue of concern for the natural environment. We propose a hierarchy of the multiplicity strength of influence of these three stakeholder groups. Potential measurement and implications are discussed. (shrink)

This is the first full-length English translation of Benjamin Constant's massive study of humanity's religious forms and development, published in five volumes between 1824 and 1831. Constant (1767-1830) regarded On Religion, worked on over the course of many years, as perhaps his most important philosophical work. He called it "the only interest, the only consolation of my life," and "the book that I was destined by nature to write." While the recent revival of interest in Constant's thought has been (...) welcome and fruitful, it has been incomplete, tending to leave out of account his writings on religion. In this connection, On Religion is essential reading and of interest for many reasons. As an analysis of humanity's religious experience, the work is notable for its methodology. Unlike previous writers with dogmatic commitments, whether theological or philosophical, Constant aimed to work with well-established facts and to relate religious forms to their historical contexts and civilizational developments. In this way, he was a precursor of the scientific study of religion. This objectivity, however, was not tantamount to moral-political neutrality. In the aftermath of the French Revolution, he wanted partisans of the new order to recognize that the religious impulse was natural to the human heart: to extirpate religion was therefore a fool's errand and worse. Likewise, he instructed religious reactionaries that history had left them behind: now the natural state of the religious sentiment was an unfettered "spirituality" left free to find new forms of expression. His counsel to contemporaries has proven prescient concerning subsequent religious developments in democratic and totalitarian societies. In his day, Constant was a consistent liberal, a life-long advocate of representative government, as well as of the central liberal arrangement concerning religion: separation of church and state. But On Religion demonstrates that principled liberalism can turn a sympathetic as well as analytic eye toward religion and, in an unbegrudging way, find an important place for it in free society. There are signs that this is a lesson that contemporary liberalism would do well to relearn. Peter Paul Seaton Jr. teaches philosophy at St. Mary's Seminary and University in Baltimore. His scholarly interests focus on the intersection of religion, politics, and philosophy. He has translated a number of works in French thought, especially political philosophy. These include works by Pierre Manent, Democracy without Nations? and Modern Liberty and Its Discontents (with Daniel J. Mahoney), Chantal Delsol, Unjust Justice, and Rémi Brague, On the God of the Christians and The Legitimacy of the Human. (shrink)

This paper concerns the relationship between epistemology and radically extended cognition. Radically extended cognition (REC) – as advanced by Andy Clark and David Chalmers – is cognition that is partly located outside the biological boundaries of the cognizing subject. Epistemologists have begun to wonder whether REC has any consequences for theories of knowledge. For instance, while Duncan Pritchard suggests that REC might have implications for which virtue epistemology is acceptable, J. Adam Carter wonders whether REC threatens anti-luck epistemology. In this (...) paper, I argue that the possibility of REC has no systematic consequences for theorizing in epistemology. I suggest an alternative relationship between the two: epistemology can play a role in diagnosing cases of REC. Thus, by establishing that entities partially located outside biological boundaries don't play certain epistemic roles, one can establish that they don't play the related cognitive roles either. I conclude the paper by illustrating this last point. (shrink)

This thesis is a study of the relationship between 'nature' and 'spirit' in the philosophies of F.W.J. Schelling and G.W.F. Hegel. I aim to show that Schelling and Hegel are involved in a shared task of conceiving spiritual freedom as a necessary outcome of nature's inner, rational development. I argue that by interpreting spirit as 'emergent' from nature, the absolute idealists develop a 'third way' beyond Cartesian dualism and monist naturalism. For on the idealist account, nature and spirit are neither (...) ontologically discontinuous, as if separated by an insurmountable 'gap', nor are they identical, as if spirit were simply a 'second nature'. Rather, according to both Schelling and Hegel, spirit emerges from nature as its ontologically distinct and non-natural telos. What makes Schelling's and Hegel's philosophies of nature so unique, however, is not simply that they present spiritual freedom as dependent upon nature, but that the ontological specificity of spirit is shown to be rationally necessary. In fact, neither the early Schelling nor Hegel is concerned with the historical emergence of spirit. Rather, both philosophers see the 'emergence' of spirit as an atemporal feature of being that must be derived through sheer reason—be it Schelling’s method of 'depotentiation' or Hegel's dialectical logic. I therefore argue that by bracketing the question of historical emergence, Schelling and Hegel each develop a distinctive logic of emergence whereby spiritual freedom is shown to be necessary thanks to the ontological structure of the impersonal, natural world. In my concluding chapter, I consider Schelling's argument in his Berlin lectures of the 1840s that the idealist logic of emergence must be supplemented with a speculative consideration of historical emergence if philosophy is to be a complete science of reality. From this perspective, it looks as though both Hegel's and the early Schelling's 'logics of emergence', despite all their promise, presuppose the idea that nature's necessary stages need not express themselves in temporal succession in order for them to be fully realised. I conclude the thesis by suggesting that Schelling's Ages of the World was meant to overcome this apparent limit of the 'logic of emergence' without abandoning its fundamental aims. For in the Ages, nature's rationally necessary development is presented as unfolding in time, and time is understood as nothing other than the actual development of nature into spirit. (shrink)

According to epistemic reductionism about practical reasons, facts about practical reasons can be reduced to facts about evidence for ought-judgements. We argue that this view misconstrues practical conflicts. At least some conflicts between practical reasons put us in a position to know that an action ϕ is optional, i.e. that we neither ought to perform nor ought to refrain from performing the action. By understanding conflicts of practical reasons as conflicts of evidence about what one ought to do, epistemic reductionism (...) fails to account for this. In conflict cases in which ϕ-ing is optional, epistemic reductionism suggests that we have equally strong evidence for and against assuming that we ought to ϕ, and thus cannot be in a position to know that it is not the case that we ought to ϕ. This is a serious flaw. (shrink)

Speakers typically use the sentence “I will go to the store” to simultaneously express an intention to go to the store and a belief that they will go to the store. This is consonant with two popular theses about intentions: first, intending to j implies believing that one will j; second, intending to j commits one to j-ing. In this paper, I argue that at least one of these theses is false. I do so by exploring what speakers express when (...) they utter a sentence with a slightly different form, like “I will probably go to the store” in a typical situation. After laying down a framework for thinking about this sort of communication, I explore some different things speakers might express with this sentence in different situations. Most importantly, I argue that in some typical situations speakers express either ordinary intentions but not beliefs or partial intentions that don’t commit them to performing the intended action. Either way, at least one of the popular theses is false. (shrink)

Rarely have I begun a book with such keen enthusiasm only later to cool to a deep but respectful ambivalence. In this clearly written and thoughtful monograph, Canadian analytic philosopher J. L. Schellenberg spurs readers to think about religion in evolutionary terms analogous to how Darwin and others have taught us to think about nature. As I will outline, I think he has mixed success in this engaging endeavor.Schellenberg’s valuable insight, and the source of my initial enthusiasm, is (...) his emphasis on the full spectrum of what he calls “deep time” (pp. 1–7). Evolutionary thinking has rightly taught us to take the long view, but it is difficult for us to fully grasp the immensity of what this means. “Evolutionary time,” he notes, “is of an extent almost beyond fathoming—that’s why scientists call it ‘deep.”’ Quoting Stephen Jay Gould, he continues: “‘[A]n abstract, intellectual understanding of deep time comes easily enough—I know how many zeroes to place after 10 when I mean billions .. (shrink)